Evidence of free radical–mediated injury (isoprostane overproduction) in scleroderma
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منابع مشابه
Platelet Isoprostane Overproduction in Diabetic Patients Treated With Aspirin
Aspirin modestly influences cardiovascular events in patients with type 2 diabetes mellitus (T2DM), but the reason is unclear. The aim of the study was to determine whether in T2DM patients aspirin enhances platelet isoprostanes, which are eicosanoids with proaggregating properties derived from arachidonic acid oxidation by platelet NOX2, the catalytic subunit of reduced NAD phosphate oxidase. ...
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Functional and structural vascular lesions have been observed in the organs involved in scleroderma. The etiology of these vascular changes is poorly understood. The ability to isolate, characterize, and maintain endothelial cells in vitro provides a target cell population to study endothelial damage in scleroderma. The present report describes the effect of scleroderma serum on endothelial, sm...
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Scleroderma, which follows rheumatoid arthritis and systemic lupus erythematosus as the third most prevalent rheumatic disorder, is poorly understood. Connective tissue abnormalities have been explored extensively (1); recently, vascular involvement has been emphasized as a unifying pathogenetic concept (2, 3). The vascular features in scleroderma include Raynaud's phenomenon; an early, edemato...
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ژورنال
عنوان ژورنال: Arthritis & Rheumatism
سال: 1996
ISSN: 0004-3591,1529-0131
DOI: 10.1002/art.1780390711